RT Journal Article
SR Electronic
T1 International Union of Pharmacology. XLVII. Nomenclature and Structure-Function Relationships of Voltage-Gated Sodium Channels
JF Pharmacological Reviews
JO Pharmacol Rev
FD American Society for Pharmacology and Experimental Therapeutics
SP 397
OP 409
DO 10.1124/pr.57.4.4
VO 57
IS 4
A1 Catterall, William A.
A1 Goldin, Alan L.
A1 Waxman, Stephen G.
YR 2005
UL http://pharmrev.aspetjournals.org/content/57/4/397.abstract
AB The family of voltage-gated sodium channels initiates action potentials in all types of excitable cells. Nine members of the voltage-gated sodium channel family have been characterized in mammals, and a 10th member has been recognized as a related protein. These distinct sodium channels have similar structural and functional properties, but they initiate action potentials in different cell types and have distinct regulatory and pharmacological properties. This article presents the molecular relationships and physiological roles of these sodium channel proteins and provides comprehensive information on their molecular, genetic, physiological, and pharmacological properties.