PT - JOURNAL ARTICLE AU - Pierre Germain AU - Pierre Chambon AU - Gregor Eichele AU - Ronald M. Evans AU - Mitchell A. Lazar AU - Mark Leid AU - Angel R. De Lera AU - Reuben Lotan AU - David J. Mangelsdorf AU - Hinrich Gronemeyer TI - International Union of Pharmacology. LX. Retinoic Acid Receptors AID - 10.1124/pr.58.4.4 DP - 2006 Dec 01 TA - Pharmacological Reviews PG - 712--725 VI - 58 IP - 4 4099 - http://pharmrev.aspetjournals.org/content/58/4/712.short 4100 - http://pharmrev.aspetjournals.org/content/58/4/712.full SO - Pharmacol Rev2006 Dec 01; 58 AB - Retinoid is a term for compounds that bind to and activate retinoic acid receptors (RARα, RARβ, and RARγ), members of the nuclear hormone receptor superfamily. The most important endogenous retinoid is all-trans-retinoic acid. Retinoids regulate a wide variety of essential biological processes, such as vertebrate embryonic morphogenesis and organogenesis, cell growth arrest, differentiation and apoptosis, and homeostasis, as well as their disorders. This review summarizes the considerable amount of knowledge generated on these receptors.