RT Journal Article SR Electronic T1 International Union of Pharmacology. LX. Retinoic Acid Receptors JF Pharmacological Reviews JO Pharmacol Rev FD American Society for Pharmacology and Experimental Therapeutics SP 712 OP 725 DO 10.1124/pr.58.4.4 VO 58 IS 4 A1 Pierre Germain A1 Pierre Chambon A1 Gregor Eichele A1 Ronald M. Evans A1 Mitchell A. Lazar A1 Mark Leid A1 Angel R. De Lera A1 Reuben Lotan A1 David J. Mangelsdorf A1 Hinrich Gronemeyer YR 2006 UL http://pharmrev.aspetjournals.org/content/58/4/712.abstract AB Retinoid is a term for compounds that bind to and activate retinoic acid receptors (RARα, RARβ, and RARγ), members of the nuclear hormone receptor superfamily. The most important endogenous retinoid is all-trans-retinoic acid. Retinoids regulate a wide variety of essential biological processes, such as vertebrate embryonic morphogenesis and organogenesis, cell growth arrest, differentiation and apoptosis, and homeostasis, as well as their disorders. This review summarizes the considerable amount of knowledge generated on these receptors.