TY - JOUR T1 - International Union of Pharmacology. LXII. The NR1H and NR1I Receptors: Constitutive Androstane Receptor, Pregnene X Receptor, Farnesoid X Receptor α, Farnesoid X Receptor β, Liver X Receptor α, Liver X Receptor β, and Vitamin D Receptor JF - Pharmacological Reviews JO - Pharmacol Rev SP - 742 LP - 759 DO - 10.1124/pr.58.4.6 VL - 58 IS - 4 AU - David D. Moore AU - Shigeaki Kato AU - Wen Xie AU - David J. Mangelsdorf AU - Daniel R. Schmidt AU - Rui Xiao AU - Steven A. Kliewer Y1 - 2006/12/01 UR - http://pharmrev.aspetjournals.org/content/58/4/742.abstract N2 - The nuclear receptors of the NR1H and NR1I subgroups include the constitutive androstane receptor, pregnane X receptor, farnesoid X receptors, liver X receptors, and vitamin D receptor. The newly emerging functions of these related receptors are under the control of metabolic pathways, including metabolism of xenobiotics, bile acids, cholesterol, and calcium. This review summarizes results of structural, pharmacologic, and genetic studies of these receptors. ER -