RT Journal Article SR Electronic T1 METABOLISM OF EPINEPHRINE AND NOREPINEPHRINE JF Pharmacological Reviews JO Pharmacol Rev FD American Society for Pharmacology and Experimental Therapeutics SP 23 OP 28 VO 6 IS 1 A1 H. BLASCHKO YR 1954 UL http://pharmrev.aspetjournals.org/content/6/1/23.abstract AB Although many details of the chemical reactions in which catechol amines are formed or destroyed remain to be elucidated, new lines of enquiry have come to the fore: these deal with the interrelations between chemical changes and spatial distribution of active substances. The adrenal medullary cell has been an object of histochemical study since the days of Vulpian and Henle; it may be hoped that the new findings will lead to an increased understanding of the mechanism by which the release of mediator is translated into secretory activity. Similarly, increased knowledge of the sites of enzymic inactivation of adrenaline and noradrenaline may pave the way for a more precise location of the sites of their biological action in the effector cell.