PT - JOURNAL ARTICLE AU - Razani, Babak AU - Woodman, Scott E. AU - Lisanti, Michael P. TI - Caveolae: From Cell Biology to Animal Physiology AID - 10.1124/pr.54.3.431 DP - 2002 Sep 01 TA - Pharmacological Reviews PG - 431--467 VI - 54 IP - 3 4099 - http://pharmrev.aspetjournals.org/content/54/3/431.short 4100 - http://pharmrev.aspetjournals.org/content/54/3/431.full SO - Pharmacol Rev2002 Sep 01; 54 AB - Among the membrane compartments of a cell, vesicles known as “caveolae” have long defied functional characterization. However, since the identification of a family of proteins termed “caveolins”, that form and reside in caveolae, a better understanding has emerged. It is now clear that caveolae do not merely play a singular role in the cell, but are pleiotropic in nature—serving to modulate many cellular functions. The purpose of this review is to explicate what is known about caveolins/caveolae and highlight growing areas of caveolar research.