RT Journal Article
SR Electronic
T1 Caveolae: From Cell Biology to Animal Physiology
JF Pharmacological Reviews
JO Pharmacol Rev
FD American Society for Pharmacology and Experimental Therapeutics
SP 431
OP 467
DO 10.1124/pr.54.3.431
VO 54
IS 3
A1 Razani, Babak
A1 Woodman, Scott E.
A1 Lisanti, Michael P.
YR 2002
UL http://pharmrev.aspetjournals.org/content/54/3/431.abstract
AB Among the membrane compartments of a cell, vesicles known as “caveolae” have long defied functional characterization. However, since the identification of a family of proteins termed “caveolins”, that form and reside in caveolae, a better understanding has emerged. It is now clear that caveolae do not merely play a singular role in the cell, but are pleiotropic in nature—serving to modulate many cellular functions. The purpose of this review is to explicate what is known about caveolins/caveolae and highlight growing areas of caveolar research.