TY - JOUR T1 - International Union of Pharmacology XLIV. Nomenclature for the Oxoeicosanoid Receptor JF - Pharmacological Reviews JO - Pharmacol Rev SP - 149 LP - 157 DO - 10.1124/pr.56.1.4 VL - 56 IS - 1 AU - Charles Brink AU - Sven-Erik Dahlén AU - Jeffrey Drazen AU - Jilly F. Evans AU - Douglas W. P. Hay AU - G. Enrico Rovati AU - Charles N. Serhan AU - Takao Shimizu AU - Takehiko Yokomizo Y1 - 2004/03/01 UR - http://pharmrev.aspetjournals.org/content/56/1/149.abstract N2 - Oxoeicosanoids are a family of biologically active arachidonic acid derivatives that have been intimately linked with cellular migration. These metabolites are not only potent chemotaxins but also elicit oxygen radical production as well as induce secretory events in different cells. The most potent native ligand reported is 5-oxo-6,8,11,14-eicosatetraenoic acid (5-oxo-ETE), and the cell membrane receptor activated has now been cloned. This receptor is distinct from those receptors activated by either the prostaglandins or the leukotrienes. The purpose of this review is to briefly summarize the molecular evidence and highlight the significance of this receptor. In addition, an official nomenclature for this oxoeicosanoid receptor is proposed. ER -