RT Journal Article
SR Electronic
T1 International Union of Pharmacology XLIV. Nomenclature for the Oxoeicosanoid Receptor
JF Pharmacological Reviews
JO Pharmacol Rev
FD American Society for Pharmacology and Experimental Therapeutics
SP 149
OP 157
DO 10.1124/pr.56.1.4
VO 56
IS 1
A1 Charles Brink
A1 Sven-Erik Dahlén
A1 Jeffrey Drazen
A1 Jilly F. Evans
A1 Douglas W. P. Hay
A1 G. Enrico Rovati
A1 Charles N. Serhan
A1 Takao Shimizu
A1 Takehiko Yokomizo
YR 2004
UL http://pharmrev.aspetjournals.org/content/56/1/149.abstract
AB Oxoeicosanoids are a family of biologically active arachidonic acid derivatives that have been intimately linked with cellular migration. These metabolites are not only potent chemotaxins but also elicit oxygen radical production as well as induce secretory events in different cells. The most potent native ligand reported is 5-oxo-6,8,11,14-eicosatetraenoic acid (5-oxo-ETE), and the cell membrane receptor activated has now been cloned. This receptor is distinct from those receptors activated by either the prostaglandins or the leukotrienes. The purpose of this review is to briefly summarize the molecular evidence and highlight the significance of this receptor. In addition, an official nomenclature for this oxoeicosanoid receptor is proposed.