RT Journal Article SR Electronic T1 Antibody Drug Conjugates for Cancer Therapy JF Pharmacological Reviews JO Pharmacol Rev FD American Society for Pharmacology and Experimental Therapeutics SP 3 OP 19 DO 10.1124/pr.114.009373 VO 68 IS 1 A1 Paul Polakis A2 Timothy A. Esbenshade YR 2016 UL http://pharmrev.aspetjournals.org/content/68/1/3.abstract AB Antibody drug conjugates (ADCs) constitute a family of cancer therapeutics designed to preferentially direct a cytotoxic drug to cells expressing a cell-surface antigen recognized by an antibody. The antibody and drug are linked through chemistries that enable release of the cytotoxic drug or drug adduct upon internalization and digestion of the ADC by the cell. Over 40 distinct ADCs, targeting an array of antigens and utilizing a variety of drugs and linkers, are undergoing clinical evaluation. This review primarily covers ADCs that have advanced to clinical investigation with a particular emphasis on how the individual targets, linker chemistries, and appended drugs influence their behavior.