TY - JOUR T1 - PHARMACOLOGY OF RENIN AND HYPERTENSIN JF - Pharmacological Reviews JO - Pharmacol Rev SP - 25 LP - 55 VL - 8 IS - 1 AU - E. BRAUN-MENÉNDEZ Y1 - 1956/03/01 UR - http://pharmrev.aspetjournals.org/content/8/1/25.abstract N2 - From the present review one important conclusion arises, i. e., that the pharmacological effects of renin are mediated through the in vivo or in vitro formation of hypertensin. Most, if not all, of the pharmacological actions of renin may be duplicated by the administration of hypertensin, if proper dosage and mode of administration are used. On the other hand, renin has no specific pharmacological action in the absence of its substrate. In spite of the fair amount of work reviewed, the pharmacology of both renin and hypertensin still requires much further study. Two aspects should receive special consideration: 1) a revision of many pharmacological reactions should be made with better methods and with purer preparations of renin and hypertensin; and 2) a definition of a unit of potency for both substances should be agreed upon by all workers in the field and there should be an international standard of a stable preparation obtainable from a central source. ER -