RT Journal Article
SR Electronic
T1 THE EFFECTS OF DRUGS ON ENZYME SYSTEMS
JF Pharmacological Reviews
JO Pharmacol Rev
FD American Society for Pharmacology and Experimental Therapeutics
SP 89
OP 135
VO 8
IS 1
A1 F. EDMUND HUNTER, JR.
A1 OLIVER H. LOWRY
YR 1956
UL http://pharmrev.aspetjournals.org/content/8/1/89.abstract
AB It is hoped the foregoing may illustrate not only the complexities of drug-enzyme interactions but also the richness of the possibilities for selective interference with enzyme systems by foreign agents. At the present time, most of the successful drugs are developed empirically or through synthesis of congeners of pre-existing successful types. One wishes for a rational approach which would permit the deliberate development of new drugs specifically to affect particular enzymes. There have been many attempts to develop drugs on a rational basis. Perhaps these attempts will be more successful in the near future. But it must be admitted that the total enzyme matrix of the living organism is more complex and subtle than formerly visualized. Although new information concerning enzymes and their sensitivity to inhibition is being obtained at a constantly accelerated rate, each increment of knowledge also shows the goal to be a little further away than it had appeared to be.