TY - JOUR T1 - ANTHELMINTICS JF - Pharmacological Reviews JO - Pharmacol Rev SP - 329 LP - 365 VL - 9 IS - 3 AU - ERNEST BUEDING AU - CLYDE SWARTZWELDER Y1 - 1957/09/01 UR - http://pharmrev.aspetjournals.org/content/9/3/329.abstract N2 - The introduction of piperazine as an agent for the treatment of ascariasis and enterobiasis and the demonstration of the broad spectrum anthelmintic activity of cyanine dyes have been the most significant developments in the field of anthelmintics during the past few years. Also, some progress has been made towards an understanding of the mechanism of action of these and of other anthelmintic agents. However, a great deal more investigative effort will be required before the wide gap is bridged between our knowledge of the morphology and taxonomy of parasitic worms on one hand, and that of their physiology and biochemistry on the other. Such information should supply a rational basis for the development of drugs for the treatment of infections produced by those helminths against which safe and effective chemotherapeutic agents as yet are not available. ER -