PT - JOURNAL ARTICLE AU - Fen Huang AU - Xiuming Wong AU - Lily Y. Jan TI - International Union of Basic and Clinical Pharmacology. LXXXV: Calcium-Activated Chloride Channels AID - 10.1124/pr.111.005009 DP - 2012 Jan 01 TA - Pharmacological Reviews PG - 1--15 VI - 64 IP - 1 4099 - http://pharmrev.aspetjournals.org/content/64/1/1.short 4100 - http://pharmrev.aspetjournals.org/content/64/1/1.full SO - Pharmacol Rev2012 Jan 01; 64 AB - Calcium-activated chloride channels (CaCCs) are widely expressed in various tissues and implicated in physiological processes such as sensory transduction, epithelial secretion, and smooth muscle contraction. Transmembrane proteins with unknown function 16 (TMEM16A) has recently been identified as a major component of CaCCs. Detailed molecular analysis of TMEM16A will be needed to understand its structure-function relationships. The role this channel plays in physiological systems remains to be established and is currently a subject of intense investigation.