RT Journal Article
SR Electronic
T1 Brain-Derived Neurotrophic Factor and Neuropsychiatric Disorders
JF Pharmacological Reviews
JO Pharmacol Rev
FD American Society for Pharmacology and Experimental Therapeutics
SP pr.111.005108
DO 10.1124/pr.111.005108
A1 Anita E. Autry
A1 Lisa M. Monteggia
YR 2012
UL http://pharmrev.aspetjournals.org/content/early/2012/03/08/pr.111.005108.abstract
AB Brain derived neurotrophic factor (BDNF) is the most prevalent growth factor in the central nervous system (CNS). It is essential for the development of the CNS and for neuronal plasticity. Because BDNF plays a crucial role in development and plasticity of the brain, it is widely implicated in psychiatric diseases. This review provides a summary of clinical and preclinical evidence for the involvement of this ubiquitous growth factor in major depressive disorder, schizophrenia, addiction, Rett syndrome, as well as other psychiatric and neurodevelopmental diseases. In addition, the review includes a discussion of the role of BDNF in the mechanism of action of pharmacological therapies currently used to treat these diseases, such antidepressants and antipsychotics. The review also covers a critique of experimental therapies such as BDNF mimetics and discusses the value of BDNF as a target for future drug development.