TABLE 2

The SLC6 neurotransmitter transporters

Transporter	Splice Variants	Size	K_M	Turnover Rate	Substrate-Ion Stoichiometry (Substrate/Na⁺/Cl⁻)
		amino acids	μM	s⁻¹
Monoamine transporters
SERT		630	0.2–1.0^{^a}	1.0–3.1^{^b}	1:1:1:1 K⁺ (out)^{^c}
NET	3^{^d}	617	0.3–1.4^{^e}	1.7–2.5^{^f}	1:1:1^{^g}
DAT		620	0.3–5.2^{^h}	0.7–1.9^ⁱ	1:2:1^{^j}
GABA transporters
GAT1		599	5.0–7.0^{^k}	6.0–93^{^l,^m}	1:2:1^ⁿ
BGT1^{^o}		614	19–120^{^p}	22^{^m,^q}	1:3:(1 or 2)^{^r}
GAT2^{^s}		602	3.0–8.0^{^t}	1.7–3.8^{^m,^u}	1:2:1^{^v}
GAT3^{^w}		632	2.3–12^{^x}	1.5–16 ^{^m,^y}	1:2:1^{^z}
Glycine transporters
GLYT1	5^{^d}	706	20–100^{^aa}	18–20^{^bb}	1:2:1^{^cc}
GLYT2	3^{^d}	797	25–94^{^dd}	20^{^ee}	1:3:1^{^cc}

↵a Blakely et al., 1991; Hoffman et al., 1991; Ramamoorthy et al., 1993; Gu et al., 1994; Chang et al., 1996; Kristensen et al., 2004; Andersen et al., 2009b; human, rat, and mouse SERT.
↵b Gu et al., 1994; Sucic and Bryan-Lluka, 2002; Quick, 2003; Kristensen et al., 2004; human and rat SERT.
↵c Talvenheimo et al., 1983; porcine SERT.
↵d Chen et al., 2004b; NET splice variants differ in the C-terminal region. GLYT1 and GLYT2 splice variants differ in their N- and C-terminal regions.
↵e Pacholczyk et al., 1991; Gu et al., 1994, 1996c; Galli et al., 1995; Paczkowski et al., 1999; human, rat, and bovine NET.
↵f Bönisch and Harder, 1986; Galli et al., 1995; Sucic and Bryan-Lluka, 2002; human and rat NET.
↵g Gu et al., 1996b; human NET.
↵h Giros et al., 1991, 1992; Kilty et al., 1991; Shimada et al., 1991; Gu et al., 1994, 1996a; human and rat DAT.
↵i Gu et al., 1994; Meiergerd et al., 1994; Lin et al., 1999; Prasad and Amara, 2001; rat DAT.
↵j Gu et al., 1994; rat DAT.
↵k Guastella et al., 1990; Loo et al., 2000; human and rat GAT-1.
↵l Mager et al., 1993; Deken et al., 2000; Fesce et al., 2002; Gonzales et al., 2007; human and rat GAT1.
↵m Electrophysiological measurements; highly dependent on temperature and membrane potential.
↵n Loo et al., 2000; human GAT1.
↵o Equivalent to mouse GAT2.
↵p Lopez-Corcuera et al., 1992; Yamauchi et al., 1992; Borden et al., 1995; Matskevitch et al., 1999; human and canine BGT-1 and mouse GAT-2.
↵q Forlani et al., 2001; canine BGT1.
↵r Matskevitch et al., 1999; canine BGT1.
↵s Equivalent to mouse GAT3.
↵t Borden et al., 1992; Sacher et al., 2002; rat GAT-2 and mouse GAT-3.
↵u Sacher et al., 2002; mouse GAT3.
↵v Sacher et al., 2002; mouse GAT3.
↵w Equivalent to mouse GAT4.
↵x Borden et al., 1992; Clark et al., 1992; Karakossian et al., 2005; rat GAT-3 and mouse GAT-4.
↵y Karakossian et al., 2005; mouse GAT4.
↵z Karakossian et al., 2005; mouse GAT4.
↵aa Guastella et al., 1992; Liu et al., 1992b; Smith et al., 1992; Kim et al., 1994; Roux and Supplisson, 2000; rat GLYT1.
↵bb Supplisson and Bergman, 1997; Supplisson and Roux, 2002; rat GLYT1.
↵cc Roux and Supplisson, 2000; rat GLYT1b and GLYT2a splice variants.
↵dd Borowsky et al., 1993; Roux and Supplisson, 2000; rat GLYT2.
↵ee Supplisson and Roux, 2002; rat GLYT2.