TABLE 6

Post-translational modifications of SLC6 neurotransmitter transporters

Transporter	Kinase	Site	References
Phosphorylation
SERT	PKA^{^a}	N- and C-terminal domains	Ramamoorthy et al., 1998a
	PKC^{^a}	N- and C-terminal domains	Ramamoorthy et al., 1998a
	PKG^{^b}	Thr276 (IL2)	Ramamoorthy et al., 2007
NET	PKC^{^a}	Thr258-Ser259 (IL2)	Jayanthi et al., 2006
	CamKII^{^c}	C-terminal domain	Uchida et al., 1998
DAT	PKC^{^a}	N-terminal Ser cluster (Ser2, Ser4, Ser7, Ser12, Ser13)	Foster et al., 2002; Lin et al., 2003; Granas et al., 2003; Cervinski et al., 2005; Gorentla et al., 2009
	CamKII^{^c}	N-terminal domain	Fog et al., 2006; Gorentla et al., 2009
	ERK1/2^{^a}	Thr53 (N-terminal domain)	Gorentla et al., 2009
	JNK^{^a}	Thr53 (N-terminal domain)	Gorentla et al., 2009
	p38 MAPK^{^a}	Thr53 (N-terminal domain)	Gorentla et al., 2009
	PKA^{^c}	N-terminal domain	Gorentla et al., 2009
	PKG^{^c}	N-terminal domain	Gorentla et al., 2009
	CKII^{^c}	N-terminal domain	Gorentla et al., 2009
	Cdk5^{^c}	N-terminal domain	Gorentla et al., 2009
	Akt^{^c}	N-terminal domain	Gorentla et al., 2009
GAT1	Tyr kinase^{^e}	Tyr107 (IL1), Tyr317 (IL3)	Whitworth and Quick, 2001
N-Linked glycosylation
SERT		Asn208, Asn217	Rasmussen et al., 2009; Tate and Blakely, 1994
NET		Asn184, Asn192, Asn198	Melikian et al., 1996; Nguyen and Amara, 1996
DAT		Asn181, Asn188, Asn205	Li et al., 2004; Torres et al., 2003a
GAT1		Asn176, Asn181, Asn184	Bennett and Kanner, 1997; Cai et al., 2005
GLYT1		Asn169, Asn172, Asn182, Asn188	Olivares et al., 1995
GLYT2		Asn345, Asn355, Asn360, Asn366	Martínez-Maza et al., 2001

JNK, c-Jun NH₂-terminal kinase; CKII, casein kinase II; Cdk5, cyclin-dependent kinase 5.
↵a Phosphorylation of functional transporter, confirmed by in vitro phosphorylation.
↵b Putative. Direct transporter phosphorylation not confirmed.
↵c In vitro phosphorylation only.
d The corresponding residue in human DAT is a Ser.
↵e Phosphorylation of functional transporter, not confirmed by in vitro phosphorylation.