TABLE 7

Protein interaction partners for the SLC6 neurotransmitter transporters

Transporter & Interaction PartnerSite of Interaction (Terminus)References
Monoamine transporters
    SERT
        SCAMP2NMüller et al., 2006
        Syntaxin1ANHaase et al., 2001; Quick, 2003
        Integrin αIIbβ3CCarneiro et al., 2008
        Hic-5CCarneiro and Blakely, 2006; Carneiro et al., 2002
        MacMARKSCJess et al., 2002
        nNOSCChanrion et al., 2007
        Sec23ACChanrion et al., 2007
        Sec24CCChanrion et al., 2007
        CIPPCChanrion et al., 2007
        α-SynucleinN.I.Wersinger et al., 2006b
        Myosin2AN.I.Ozaslan et al., 2003
        PP2AN.I.Bauman et al., 2000
    NET
        14-3-3 proteinsNSung et al., 2005
        PP2ANBauman et al., 2000; Sung et al., 2005
        Syntaxin1ANSung et al., 2003
        HIC-5CCarneiro et al., 2002
        PICK1CTorres et al., 2001
        α-SynucleinN.I.Wersinger et al., 2006a
        SNAP-25N.I.Schroeter et al., 2000
        SynaptophysinN.I.Schroeter et al., 2000
    DAT
        D2 ReceptorNBolan et al., 2007; Lee et al., 2007
        SynaptogyrinNEgaña et al., 2009
        Syntaxin1ANLee et al., 2004
        SCAMP2NMüller et al., 2006
        CaMKIICFog et al., 2006
        Hic-5CCarneiro et al., 2002
        PICK1CTorres et al., 2001
        α-SynucleinCLee et al., 2001; Wersinger et al., 2003
        ParkinN.I.Moszczynska et al., 2007
        PP2AN.I.Bauman et al., 2000
        PKCβN.I.Johnson et al., 2005b
        NEDD4-2N.I.Sorkina et al., 2006
        Epsin/Eps15N.I.Sorkina et al., 2006
        GPR37N.I.Marazziti et al., 2007
        ParkinN.I.Moszczynska et al., 2007
GABA transporters
    GAT-1
        Syntaxin1ANBeckman et al., 1998; Deken et al., 2000
        ARFGAP1CReiterer et al., 2008
        Pals1CMcHugh et al., 2004
        Sec24DCFarhan et al., 2004, 2007
Glycine transporters
    GLYT1
        PSD-95CCubelos et al., 2005b
        Sec3CCubelos et al., 2005a
        Syntaxin1AN.I.Geerlings et al., 2000
    GLYT2
        Ulip6NHoriuchi et al., 2000, 2005
        Syntenin-1COhno et al., 2004
        Syntaxin1AN.I.Geerlings et al., 2000, 2001
  • N.I., not identified; CIPP, channel-interacting PDZ protein; SNAP-25, synaptosome-associated protein 25; NEDD4-2 (neural precursor cell expressed, developmentally down-regulated 4-2); GPR37, G protein-coupled receptor 37; ARFGAP1, ADP-ribosylation factor GTPase-activating protein 1; Pals1, protein associated with Lin seven 1; Ulip6, Unc-33-like protein 6.