Dissociation constants of ryanodine analogs used for the initial basis set
| Compound Number | Compound | Rabbit KDnm | Chicken KD nm |
|---|---|---|---|
| 1 | ryanodine | 7 | 7 |
| 55 | dehydroryanodine | 7 | 6 |
| 65 | ester A | 110 | 130 |
| 61 | ester B | 240 | 240 |
| 62 | ester C1 | 210 | 300 |
| 71 | ester C2 | 2600 | 3600 |
| 66 | ester D | 51 | 63 |
| 63 | ryanodyl nicotinate | 1100 | 1400 |
| 2 | ryanodol | 12000 | 3600 |
| 57 | 9-hydroxyryanodine | 110 | 110 |
| 4 | anhydroryanodine | 2900 | 3000 |
| 70 | anhydroester A | 5200 | 8100 |
| 117 | 9-epiryanodine | 13 | 13 |
| 120 | 9β,21-epoxyryanodine | 36 | 29 |
| 122 | 21-azido-9-hydroxyryanodine | 78 | 87 |
| 124 | 21-p-nitrobenzamido-ryanodine | 22 | 22 |
| 125 | 21-bodipy-ryanodine | 13 | 13 |
| 132 | 8α-amino-9β-hydroxyryanodine | 3800 | 3800 |
| 131 | 8β-amino-9α-hydroxyryanodine | 760 | 760 |
Rabbit and avian skeletal muscle KD calculated using competitive binding of ryanodine against modified ryanodine in microsomal membranes.