Table 2

Potencies of dopaminergic agonists at D₃ and D₂dopamine receptors in in vitro functional assays

Compound	Assay	D₂Source	D₃Source	EC₅₀ (nM)
Compound	Assay	D₂Source	D₃Source	D₂	D₃	EC₅₀_(D₂₎EC₅₀_(D₃₎	Reference
Dopamine	inhibition of adenylyl cyclase	rD_2L/CHO 10001	rD₃/CHO 10001	13.0	16	0.81	Chio et al. (1994)
	mitogenesis	rD_2L/CHO 10001	rD₃/CHO 10001	5.4	2.2	2.5	Chio et al. (1994)
	mitogenesis	hD_2S/CHO	hD₃/NG108-15	20	1.4	15	Sautel et al. (1995a)
	melanocyte aggregation	hD₂/Xenopus melanocytes	hD₃/Xenopus melanocytes	154	295	0.52	Potenza et al. (1994)
	extracellular acidifcation	hD_2L/CHO	hD₃/CHO	174	30	5.8	Boyfield et al. (1996)

Bromocriptine	mitogenesis	hD_2S/CHO	hD₃/NG108-15	1.8	12	0.15	Sautel et al. (1995)
	melanocyte aggregation	hD₂/Xenopus melanocytes	hD₃/Xenopus melanocytes	24.5	43.5	0.56	Potenza et al. (1994)

Apomorphine	inhibition of adenylyl cyclase	rD_2L/CHO 10001	rD₃/CHO 10001	46	79	0.58	Chio et al. (1994)
	mitogenesis	rD_2L/CHO 10001	rD₃/CHO 10001	0.40	1.1	0.36	Chio et al. (1994)
	mitogenesis	hD_2S/CHO	hD₃/NG108-15	2.3	2.2	1.1	Sautel et al. (1995)

Quinpirole	inhibition of adenylyl cyclase	rD_2L/CHO 10001	rD₃/CHO 10001	6.0	3.7	1.6	Chio et al. (1994)
	mitogenesis	rD_2L/CHO 10001	rD₃/CHO 10001	2.2	1.7	1.3	Chio et al. (1994)
	mitogenesis	hD_2S/CHO	hD₃/NG108-15	2.8	0.86	3.3	Sautel et al. (1995)
	mitogenesis	hD_2L/CHO-P5	hD₃/CHO-P5	7.1	2.8	2.5	Pugsley et al. (1995)
	melanocyte aggregation	hD₂/Xenopus melanocytes	hD₃/Xenopus melanocytes	10.9	15.4	0.71	Potenza et al. (1994)
	extracellular acidification	hD_2L/CHO	hD₃/CHO	52	2.09	25	Boyfield et al. (1996)

7-OH-DPAT	inhibition of adenylyl cyclase	rD_2L/CHO 10001	rD₃/CHO 10001	1.1	0.08	14	Chio et al. (1994)
	mitogenesis	rD_2L/CHO 10001	rD₃/CHO 10001	1.1	0.30	3.7	Chio et al. (1994)
	mitogenesis	hD_2S/CHO	hD₃/NG108-15	2.7	0.39	7.0	Sautel et al. (1995)
	melanocyte aggregation	hD₂/Xenopus melanocytes	hD₃/Xenopus melanocytes	56.2	113	0.50	Potenza et al. (1994)
	extracellular acidification	hD_2L/CHO	hD₃/CHO	8.31	1.10	7.5	Boyfield et al. (1996)

(−)-3-PPP	inhibition of adenylyl cyclase	rD_2L/CHO 10001	rD₃/CHO 10001	9.7	3.9	2.5	Chio et al. (1994)
	mitogenesis	rD_2L/CHO 10001	rD₃/CHO 10001	9.5	23	0.41	Chio et al. (1994)
	mitogenesis	hD_2S/CHO	hD₃/NG108-15	9.1	4.4	2.1	Sautel et al. (1995)
	melanocyte aggregation	hD₂/Xenopus melanocytes	hD₃/Xenopus melanocytes	1103	1102	1.0	Potenza et al. (1994)
PD128907	mitogenesis	hD_2L/CHO-P5	hD₃/CHO-P5	10	1.58	6.3	Pugsley et al. (1995)

r, rat; h, human.