Compound | Assay | D2Source | D3Source | EC50 (nM) | |||
---|---|---|---|---|---|---|---|
D2 | D3 | EC50(D2)EC50(D3) | Reference | ||||
Dopamine | inhibition of adenylyl cyclase | rD2L/CHO 10001 | rD3/CHO 10001 | 13.0 | 16 | 0.81 | Chio et al. (1994) |
mitogenesis | rD2L/CHO 10001 | rD3/CHO 10001 | 5.4 | 2.2 | 2.5 | Chio et al. (1994) | |
mitogenesis | hD2S/CHO | hD3/NG108-15 | 20 | 1.4 | 15 | Sautel et al. (1995a) | |
melanocyte aggregation | hD2/Xenopus melanocytes | hD3/Xenopus melanocytes | 154 | 295 | 0.52 | Potenza et al. (1994) | |
extracellular acidifcation | hD2L/CHO | hD3/CHO | 174 | 30 | 5.8 | Boyfield et al. (1996) | |
Bromocriptine | mitogenesis | hD2S/CHO | hD3/NG108-15 | 1.8 | 12 | 0.15 | Sautel et al. (1995) |
melanocyte aggregation | hD2/Xenopus melanocytes | hD3/Xenopus melanocytes | 24.5 | 43.5 | 0.56 | Potenza et al. (1994) | |
Apomorphine | inhibition of adenylyl cyclase | rD2L/CHO 10001 | rD3/CHO 10001 | 46 | 79 | 0.58 | Chio et al. (1994) |
mitogenesis | rD2L/CHO 10001 | rD3/CHO 10001 | 0.40 | 1.1 | 0.36 | Chio et al. (1994) | |
mitogenesis | hD2S/CHO | hD3/NG108-15 | 2.3 | 2.2 | 1.1 | Sautel et al. (1995) | |
Quinpirole | inhibition of adenylyl cyclase | rD2L/CHO 10001 | rD3/CHO 10001 | 6.0 | 3.7 | 1.6 | Chio et al. (1994) |
mitogenesis | rD2L/CHO 10001 | rD3/CHO 10001 | 2.2 | 1.7 | 1.3 | Chio et al. (1994) | |
mitogenesis | hD2S/CHO | hD3/NG108-15 | 2.8 | 0.86 | 3.3 | Sautel et al. (1995) | |
mitogenesis | hD2L/CHO-P5 | hD3/CHO-P5 | 7.1 | 2.8 | 2.5 | Pugsley et al. (1995) | |
melanocyte aggregation | hD2/Xenopus melanocytes | hD3/Xenopus melanocytes | 10.9 | 15.4 | 0.71 | Potenza et al. (1994) | |
extracellular acidification | hD2L/CHO | hD3/CHO | 52 | 2.09 | 25 | Boyfield et al. (1996) | |
7-OH-DPAT | inhibition of adenylyl cyclase | rD2L/CHO 10001 | rD3/CHO 10001 | 1.1 | 0.08 | 14 | Chio et al. (1994) |
mitogenesis | rD2L/CHO 10001 | rD3/CHO 10001 | 1.1 | 0.30 | 3.7 | Chio et al. (1994) | |
mitogenesis | hD2S/CHO | hD3/NG108-15 | 2.7 | 0.39 | 7.0 | Sautel et al. (1995) | |
melanocyte aggregation | hD2/Xenopus melanocytes | hD3/Xenopus melanocytes | 56.2 | 113 | 0.50 | Potenza et al. (1994) | |
extracellular acidification | hD2L/CHO | hD3/CHO | 8.31 | 1.10 | 7.5 | Boyfield et al. (1996) | |
(−)-3-PPP | inhibition of adenylyl cyclase | rD2L/CHO 10001 | rD3/CHO 10001 | 9.7 | 3.9 | 2.5 | Chio et al. (1994) |
mitogenesis | rD2L/CHO 10001 | rD3/CHO 10001 | 9.5 | 23 | 0.41 | Chio et al. (1994) | |
mitogenesis | hD2S/CHO | hD3/NG108-15 | 9.1 | 4.4 | 2.1 | Sautel et al. (1995) | |
melanocyte aggregation | hD2/Xenopus melanocytes | hD3/Xenopus melanocytes | 1103 | 1102 | 1.0 | Potenza et al. (1994) | |
PD128907 | mitogenesis | hD2L/CHO-P5 | hD3/CHO-P5 | 10 | 1.58 | 6.3 | Pugsley et al. (1995) |
r, rat; h, human.