Histamine | H1 100 | H2 100 | H3 100 |
---|---|---|---|
2-(3-(Trifluoromethyl)phenyl)histamine | 1282-a | <0.12-a | n.d. |
2-(3-Bromophenyl)histamine | 1122-a | <0.12-a | n.d. |
Nα-methylhistamine | 722-b | 742-c | 2702-d |
2-(2-Thiazolyl)ethylamine | 262-b | 2.22-b | <0.0082-d |
2-Methylhistamine | 172-c | 42-c | <0.082-d |
2-(2-Pyridyl)ethylamine | 5.62-b | 2.52-b | n.d. |
Arpromidine | Antagonist2-e | 10,2302-e | |
Impromidine | Antagonist2-f | 4,8102-f | Antagonist2-d , 2-o |
Sopromidine | 22-g | 7402-g | Antagonist2-h , 2-p |
Amthamine | 12-i | 1502-i | 0.0022-i |
Dimaprit | <0.00012-j | 712-j | Antagonist2-d , 2-q |
4-Methylhistamine | 0.22-c | 432-c | <0.0082-d |
Imetit | <0.12-k | 0.62-k | 62002-k |
Immepip | n.d. | n.d. | 24572-l |
R-α-methylhistamine | 0.52-m | 12-m | 15502-m |
S-α-methylhistamine | 0.52-b | 1.72-b | 132-m |
R-α,S-β-dimethylhistamine | 0.072-n | 0.12-n | 18002-n |
Values determined from guinea pig ileum contraction (H1), guinea pig atrium (chronotropic stimulation, H2), and inhibition of K+-stimulated histamine release from rat cerebral cortical slices (H3), or inhibition of electrically stimulated contraction of guinea pig ileum (H3). n.d., not determined.
↵2-a Leschke et al. (1995)
↵2-b Ganelin (1982)
↵2-c Black et al. (1972)
↵2-d Arang et al. (1983)
↵2-e Sellier et al. (1992)
↵2-f Durant et al. (1978)
↵2-g Elz et al. (1989)
↵2-h Arrang et al. (1985c)
↵2-i Eriks et al. (1992)
↵2-j Durant et al. (1977)
↵2-k Garbarg et al. (1992)
↵2-l Vollinga et al. (1994)
↵2-m Arrang et al. (1987)
↵2-n Lipp et al. (1992)
↵2-o See table4.
↵2-p KB = 56 nM.
↵2-q KB = 3 μM.