“Nonsedating” H1-receptor antagonists
| Agent | pKi value | Reference |
|---|---|---|
| Temelastine | 9.5 | Ter Laak et al. (1993) |
| Acrivastine | 9.2 | Leurs et al. (1995b) |
| Epinastine | 8.9 | Ter Laak et al. (1994) |
| Astemizole | 8.3 | Ter Laak et al. (1993) |
| Cetirizine | 7.5 | Ter Laak et al. (1993) |
| Terfenadine | 7.1 | Ter Laak et al. (1993) |
| Loratidine | 6.8 | Ter Laak et al. (1993) |
Values are pKi (−log dissociation constant) determined from inhibition of [3H]mepyramine binding in homogenates of guinea pig cerebellum.