Pulmonary tumors in newborn mice treated with BP and stereoisomers of BP-7,8-diol-9,10 epoxides
| Compound number | Treatment | Total doses (nmol) | Mice with tumors (%) | Tumors/mouse |
|---|---|---|---|---|
| 1 | Control (DMSO) | 0 | 11 | 0.12 |
| 2 | BP | 7 | 18 | 0.22 |
| 3 | (−)-BP-7β,8α-diol 9β,10β epoxide 1 | 7 | 13 | 0.15 |
| 4 | (+)-BP-7α,8β-diol 9α,10α epoxide 1 | 7 | 14 | 0.15 |
| 5 | (−)-BP-7α,8β-diol 9β,10β epoxide 2 | 7 | 9 | 0.09 |
| 6 | (+)-BP-7β,8α-diol 9α,10α epoxide 2 | 7 | 71 | 1.72 |
| 2 | BP | 14 | 14 | 0.15 |
| 3 | (−)-BP-7β,8α-diol 9β,10β epoxide 1 | 14 | 22 | 0.25 |
| 4 | (+)-BP-7α,8β-diol 9α,10α epoxide 1 | 14 | 15 | 0.34 |
| 5 | (−)-BP-7α,8β-diol 9β,10β epoxide 2 | 14 | 12 | 0.13 |
| 6 | (+)-BP-7β,8α-diol, 9α,10α epoxide 2 | 14 | 100 | 7.67 |
Data excerpted with permission from Buening et al. (1978). DMSO, dimethyl sulfoxide.