Incidence of respiratory tract tumors in Fischer 344 rats receiving subcutaneous injections of NNK for 20 weeks
| Dose | Rats with nasal tumors (%) | Rats with lung tumors (%) |
|---|---|---|
| 1 mmol/kg | ||
| Males | 74 | 85 |
| Females | 37 | 30 |
| 3 mmol/kg | ||
| Males | 87 | 87 |
| Females | 80 | 47 |
| 9 mmol/kg | ||
| Males | 93 | 93 |
| Females | 93 | 60 |
Data excerpted from Hoffmann et al. (1984).