O6-MG (pmol/μmol guanine) | Alkylation efficiency (O6-MG/dose) | |
---|---|---|
Whole lung | 0.9 | 3.0 |
Alveolar macrophages | 3.8 | 12.7 |
Type II cells | 1.1 | 3.7 |
Clara cells | 28.2 | 93.2 |
Male Fischer 344 rats were injected intraperitoneally with 0.3 mg NNK/kg/day for 4 days and killed 4 h after the last dose. Data excerpted with permission from Belinsky et al. (1987).