Effect of NNK treatment (10 mg/kg/day for 4 days) on O6-MGMT activity in lung cells of Fischer 344 rats
| O6-MGMT activity (pmol/O6-MG/μmol guanine) | ||
|---|---|---|
| Vehicle control | NNK | |
| Alveolar macrophages | 31.1 | 28.2 |
| Type II cells | 32.5 | 6.0 |
| Clara cells | 15.2 | not detectable |
Data excerpted with permission from Belinsky et al. (1988).