Relation between NNK dose and content of O6-MG in specific pulmonary cell types of male Fischer rats
| Dose (mg/kg) | O6-MG (pmol/μmol guanine) | |||
|---|---|---|---|---|
| Whole lung | Macrophages | Type II cells | Clara cells | |
| 0.1 | 0.4 | 1.8 | 0.1 | 3.4 |
| 0.3 | 0.7 | 3.9 | 0.6 | 19.2 |
| 1.0 | 2.2 | 36.2 | 1.1 | 67.4 |
| 10.0 | 6.8 | 60.5 | 5.3 | 85.3 |
Data excerpted with permission from Belinsky et al. (1990).