Effects of tamoxifen on serum lipids
| Study | Total cholesterol (mg/dl) | LDL cholesterol (mg/dl) | HDL cholesterol (mg/dl) | TT | %change | ||||
|---|---|---|---|---|---|---|---|---|---|
| Control (no. of patients) | TT3-b (no. of patients) | %change | Control | TT | %change | Control | |||
| Rossner and Wallgren, 1984 | 302 (10) | 258 (11) | −15% | 201 | 156 | −22% | 87 | 75 | NS |
| Bruning et al., 1988 | 220 (46) | 205 (46) | −7% | 151 | 124 | −18% | 43 | 50 | NS |
| Bertelli et al., 1988 | 254 (36) | 213 (55) | −16% | 180 | 127 | −29% | 55 | 56 | NS |
| Bagdade et al., 1990 | 193 (8) | 204 (8) | NS | 122 | 115 | −6% | 45 | 49 | NS |
| Love et al., 1991 | 216 (70) | 190 (70) | −12% | 138 | 110 | −20% | 57 | 53 | NS |
| Ingram, 1990 | 259 (47) | 234 (13) | −9% | 193 | 171 | −10% | 66 | 61 | NS |
| Cuzick et al., 1992 | 256 (47) | 225 (14) | −12% | 186 | 145 | −22% | 50 | 43 | −14% |
| Dnistrian et al., 1993 | 244 (13) | 203 (24) | −17% | 169 | 123 | −27% | 55 | 56 | NS |
| Thangaraju et al., 1994 | 224 (45) | 190 (39) | −15% | 149 | 132 | −17% | 54 | 58 | 7% |
| Average | 249 | 214 | −13% | 165 | 134 | −19% | 57 | 52 | NS |
3-a The summation of nine studies examining the effects of tamoxifen therapy on serum lipid profiles in women (adapted fromBilimoria et al., 1996a).
↵3-b TT, tamoxifen-treated group; NS, not statistically significant.