Table 1

Free energy of ligand/protein interactions according to K_dand appropriate examples of anesthetic-like compounds for each range

K_d, M	ΔG°, kcal/mol		Anesthetic	Reference
K_d, M	25°C	37°C	Anesthetic	Reference
1.0	0	0	Methanol	Alifimoff et al. (1989)
0.1	−1.4	−1.4	Ethanol	Alifimoff et al. (1989)
0.01	−2.7	−2.8	Diethylether	Franks and Lieb (1993)
0.001	−4.1	−4.3	Chloroform	Franks and Lieb (1994)
0.0001	−5.5	−5.7	Halothane	Franks and Lieb (1994)
0.00001	−6.8	−7.1	Barbiturates	Franks and Lieb (1994)
0.000001	−8.2	−8.5	Propofol	Franks and Lieb (1994)
0.00000001	−10.9	−11.4	Opiates	Kosterlitz and Waterfield (1975)