Muscarinic receptor genes
| Species | SwissProt accession code Number of amino acids (% identity with human sequence) | |||||||
|---|---|---|---|---|---|---|---|---|
| M1 | M2 | M3 | M4 | M5 | ||||
| Human | P11229 | P08172 | P20309 | P08713 | P08912 | |||
| 460 | 466 | 590 | 479 | 532 | ||||
| Pig | P04761 | P06199 | P11483 | |||||
| 460 (99%) | 466 (97%) | 590 (96%) | ||||||
| Cow | P41984 | |||||||
| 590 (95%) | ||||||||
| Rat | P08482 | P10980 | P08483 | P08485 | P08911 | |||
| 458 (99%) | 466 (95%) | 589 (92%) | 478 (95%) | 531 (89%) | ||||
| Mouse | P12657 | P30544 | ||||||
| 460 (98%) | 479 (95%) | |||||||
| Xenopus 2-a | P30544 | |||||||
| 484 (78%) | ||||||||
| Chicken2-a | P30372 | P49578 | P17200 | |||||
| 466 (92%)2-b | 639 (87%) | 490 (76%) | ||||||
↵2-a The nonmammalian Xenopus and chicken receptors have been included for comparison. A Drosophilamuscarinic receptor (P13695, 722aa) also has been cloned (Shapiroet al., 1989; Onai et al., 1989), but its sequence does not fit into the current classification.
↵2-b Unusual pharmacology, with approximately ten times higher pirenzepine affinity than mammalian M2 receptors (Tietje and Nathanson, 1991).
From Hulme et al. (1990); Hall et al. (1993);Herrera et al. (1994); Eglen et al. (1996), and the SwissProt database.