Distribution of drug metabolizing enzymes in kidney zones
| Enzyme | Cortex | Medulla | Outer | Inner |
|---|---|---|---|---|
| N-acetyltransferase | ✓ | ✓ | — | — |
| Alcohol dehydrogenase | ✓ | ✓ | — | — |
| Aldose reductase | — | — | ✓ | ✓ |
| Aldehyde reductase | ✓ | — | — | — |
| Amino acid conjugation | ✓ | — | — | — |
| Cytochrome P450 | ✓5-a | — | ✓ | — |
| Carboxylesterase | ✓ | — | — | — |
| Cysteine conjugate β-lyase | ✓ | — | — | — |
| Glutathione S-transferase | ✓ | ✓ | — | — |
| Monamine oxidase | ✓5-a | ✓ | — | — |
| NADPH-cytochrome c reductase | ✓5-a | — | — | ✓ |
| Steroid 21 hydroxylase | ✓ | ✓ | — | — |
| Sulfotransferase | ✓ | — | ✓ | — |
↵5-a Signifies greatest activity.