Fabs | EG | XG | EH | XH | |
---|---|---|---|---|---|
Rifampicin | 100% | 0.65 | 1.31 | 0.33 | 1.40 |
86% | 0.59 | 1.40 (XG = XH) | |||
77% | 0.54 | 1.49 | |||
65% | 0.46 | 1.68 | |||
Ketoconazole | 100% | 0.71 | 0.49 | 0.14 | 0.56 |
86% | 0.66 | 0.36 | |||
77% | 0.62 | 0.25 | |||
65% | 0.55 | Indeterminate | |||
Erythromycin | 100% | 0.51 | 0.44 | 0.20 | 0.78 |
86% | 0.43 | 0.23 | |||
77% | 0.37 | Indeterminate |
Fabs, Fraction of the drug dose absorbed into and through the gastrointestinal membranes.
EG, EH, Gut and hepatic extraction ratio, respectively.
XG, XH, Changes in EG and EH, respectively, during coadministration of the interacting drug.