Inhibition of tolbutamide metabolism (CYP2C9) by coadministration of sulfaphenazole
| Dose (mg) | Route | AUC (ng · hr/ml) | CLtot(ml/min) | ||
|---|---|---|---|---|---|
| control | 500 | p.o. | 587 | 27.5 | |
| + sulfaphenazole | 3100 | ||||
| CLr(ml/min) | CLh (ml/min) | CLh,m 2-a(ml/min) | CLh,m/CLtot | Iin,u/Ki | |
| 0.42 | 27.1 | 21.7 | 0.8 | 125–250 | |
↵2-a methyl hydroxylation (2C9) + carboxylation (sequential).