Table 6
Inhibition of imipramine metabolism (CYP2D6) by coadministration of fluoxetine
Dose (mg)
Route
AUC (ng · hr/ml)
CL
tot
(ml/min)
control
50
p.o.
372
537
+ fluoxetine
703
CL
r
(ml/min)
CL
h
(ml/min)
CL
h,m
6-a
(ml/min)
CL
h,m
/CL
tot
I
in,u
/K
i
negligible
537
96.7
0.18
0.066
↵
6-a
2-hydroxylation.