Inhibition of caffeine metabolism (CYP1A2) by coadministration of ciprofloxacin
| Dose (mg) | Route | AUC (ng · hr/ml) | CLtot (ml/min) | ||
|---|---|---|---|---|---|
| control | 220–230 | p.o. | 22.4 | 84.0 | |
| + ciprofloxacin | 35.2 | ||||
| CLr(ml/min) | CLh (ml/min) | CLh,m 7-a(ml/min) | CLh,m/CLtot | Iin,u/Ki | |
| negligible | 84.0 | 66.4 | 0.79 | 0.07–0.15 | |
↵7-a 1-demethylation + 3-demethylation + 7-demethylation + 8-hydroxylation.