Table 12

Cloned P2Y receptors

Receptor	Number of amino acids	cDNA library source	Agonist activity	References
P2Y₁	362	Human brain	2MeSATP > ATP ≫ UTP	Schachter et al., 1996
		Human prostate and ovary	2MeSATP > ATP = ADP	Janssens et al., 1996
		Human placenta	—	Léon et al., 1995, 1997
		Human HEL cells	—	Ayyanathan et al., 1996
		Bovine endothelium	2MeSATP = ADP > ATP ≫ UTP	Henderson et al., 1995
		Rat insulinoma cells	2MeSATP > 2Cl-ATP > ATP (α,β-meATP inactive)	Tokuyamaet al., 1995
		Rat ileal myocytes	2MeSATP = 2ClATP > ADP > ATP (UTP inactive)	Pacaud et al., 1996
		Mouse insulinoma cells	—	Tokuyama et al., 1995
		Turkey brain	2MeSATP > ADP > ATP (UTP inactive)	Filtz et al., 1994
		Chick brain	2MeSATP > ATP > ADP (UTP inactive)	Webb et al., 1993b

P2Y₂	373	Human CF/T43 epithelial cells	ATP = UTP ≫ 2MeSATP	Parr et al., 1995
		Human bone	—	Bowler et al., 1995
		Rat microvascular coronary EC	—	Gödecke et al., 1996
		Rat alveolar type II cells	ATP = UTP	Rice et al., 1995
		Rat pituitary	ATP = UTP > ADP = UDP > GTP	Chen et al., 1996b
		Wistar Kyoto rat^13-a	—	Seye et al., 1996
		Mouse NG108-15 neuroblastoma cells	ATP = UTP > ATPγS ≫ 2MeSATP	Lustig et al., 1993

p2y3^13-b	328	Chick brain	UDP > UTP > ADP > 2MeSATP > ATP	Webb et al., 1995, 1996a

P2Y₄	352	Human placenta	UTP > ATP = ADP^13-c	Communi et al., 1996b
		Human placenta	—	Stam et al., 1996
		Human chromosome X	UTP > UDP (ATP inactive)	Nguyenet al., 1996
		Rat heart	ATP = UTP = ADP = ITP = ATPγS = 2MeSATP = Ap₄A > UDP	Bogdanov et al., 1998

P2Y₆	379	Human placenta and spleen	UDP > UTP > ADP > 2MeSATP ≫ ATP	Communi et al., 1996b
		Rat aortic smooth muscle	UTP > ADP = 2MeSATP > ATP	Chang et al., 1995
		Activated T-cells	—	Southey et al., 1996

P2Y₁₁	371	Human placenta	ATP > 2MeSATP >>> ADP (UTP, UDP inactive)	Communi et al., 1997

↵13-a Tissue not specified.
↵13-b p2y3 may be the chick homologue of the mammalian P2Y₆ receptor.
↵13-c The reported activity of UDP at the P2Y₄ receptor has been shown to be caused by UTP present as a contaminant.