Table 13

Functional distribution of P2Y receptors

	P2Y₁-like^14-a	P2Y₂-like^14-b	P2Y_ADP^14-c	Uridine nucleotidespecific	References
Alveolar type II cells	Yes	Yes	—	—	Rice and Singleton, 1987; Rice et al., 1995
Astrocytes	Yes	Yes	—	—	Pearce and Langley, 1994;Salter and Hicks, 1994; Ho et al., 1995; Chen and Chen, 1996
Blood cells
Erythrocytes	Yes	—	—	—	Boyeret al., 1989, 1994
Erythroleukemic (human HEL megakaryocytes)	Yes	Yes	Yes	—	Shi et al., 1995
Leukemic basophils (rat mast cells)	Yes	—	—	—	Osipchuk and Cahalan, 1992; Qian and McCloskey, 1993
T-leukemia cells	Yes^d,e	—	Yes^14-e	—	Biffen and Alexander, 1994
Macrophages	—	Yes	—	Yes	Greenberg et al., 1988; Nuttle et al., 1993; Lin and Lee, 1996
Megakaryocytes	—	—	Yes	—	Vittet et al., 1992; Uneyama et al., 1994
Monocytes (murine J774)	Yes	—	—	—	Fan and McCloskey, 1994
Myelomonocytic leukemic (M1)	Yes	—	—	—	Yamaguchi et al., 1994
Neutrophils	—	Yes	—	—	Zhang et al., 1996
Platelets	Yes	—	Yes	—	Hourani et al., 1992; Hall and Hourani, 1993; Hechler et al., 1998; Fagura et al., 1998; Daniel et al., 1998;Jin, et al., 1998
CHO cells	Yes	Yes	—	—	Iredale and Hill, 1993
Chondrocytes	—	Yes	—	—	Kaplan et al., 1996
Chromaffin cells	Yes	Yes	—	—	Reichsmanet al., 1995
Duct cells
Pancreatic; cystic fibrosis	—	Yes	—	—	Chan et al., 1996
Submandibular	—	Yes	—	—	Yu and Turner, 1991
Endothelium	Yes^14-d	Yes	—	—	Motte et al., 1993a,b; Briner and Kern, 1994; Purkiss et al., 1993, 1994; Wilkinson et al., 1994; Communiet al., 1995; Nobles et al., 1995; Miyagiet al., 1996b; Ralevic and Burnstock, 1996a,b; Ralevicet al., 1991b, 1997; Simonsen et al., 1997
	Yes	Yes	—	Yes	Yang et al., 1996
Epithelium
Intestinal, apical; human	—	Yes	—	Yes	Inoue et al., 1997
Intestinal, basolateral; human	Yes	Yes	—	—	Inoueet al., 1997
Intrahepatic biliary; human	—	Yes	—	—	Wolkoff et al., 1995
Mammary tumour; mouse	—	Yes	—		Enomoto et al., 1994
Mammary tumour; human	Yes	Yes	—	—	Flezar and Heisler, 1993
MDCK cells; canine	Yes	Yes	—	—	Zegarra-Moran et al., 1995; Firestein et al., 1996; Yang et al., 1997
Nasal mucosa; human	—	?^14-f	—	Yes	Lazarowskiet al., 1997b
Ocular ciliary; human	—	Yes	—	—	Wax et al., 1993
Otocyst; embryonic chick	Yes	—	—	—	Nakaoka and Yamashita, 1995
Pancreatic; human cystic fibrosis	—	Yes	—	—	Chan et al., 1996;Montserrat et al., 1996
Retinal pigment epithelium	—	Yes^14-g	—	—	Peterson et al., 1997
Tracheal; hamster	—	Yes	—	—	Abdullah et al., 1996;Kim et al., 1996
Tracheal; rabbit	Yes	Yes	—	—	Aksoy et al., 1995
Thymic; rat	?^14-h	?^14-h	—	?^14-h	Liuet al., 1995
Submandibular salivary; mouse	Yes	Yes	—	—	Gibb et al., 1994
Sweat gland; equine	Yes	Yes	—	—	Ko et al., 1994
Fibroblasts	—	Yes	—	—	Fineet al., 1989; Gonzalez et al., 1989b,c; Marsaultet al., 1992; Grierson and Meldolesi, 1995a,b
Glial cells
Enteric glia	—	Yes	—	—	Kimball and Mulholland, 1996
Bergmann glia (cerebellar)	Yes	—	—	—	Kirischuk et al., 1995b
Microglia	Yes	—	—	Yes	Nörenberget al., 1997
Oligodendrocytes; cortical	Yes	—	—	—	Kirischuk et al., 1995a
Oligodendrocytes; retinal	—	Yes	—	—	Kirischuket al., 1995a
Glioma
C6/C6-2B glioma cells	Yes	Yes	—	Yes^14-i	Boyer et al., 1994, 1995, 1996; Munshi et al., 1993; Lin and Chuang, 1994;Nicholas et al., 1996; Schachter et al., 1996
Neuroblastoma × glioma hybrid	Yes	Yes	—	—	Linet al., 1993; Filippov et al., 1994; Reiseret al., 1995
Goblet (tracheal SPOC1) cells	—	Yes	—	—	Abdullah et al., 1996
Hepatocytes	Yes^14-d	Yes	—	—	Charest et al., 1985; Keppens and DeWulf, 1991; Keppens et al., 1992; Dixon et al., 1995
Keratinocytes	—	Yes	—	—	Pillai and Bikle, 1992
Kidney tubules
Cortical thick ascending limbs	—	Yes	—	—	Paulais et al., 1995
Cortical tubules	Yes	—	—	—	Cha et al., 1995
Terminal inner medullary collecting duct	—	Yes	—	—	Ecelbarger et al., 1994
Mesangial cells (renal)	Yes	Yes	—	—	Huwiler and Pfeilschifter, 1994; Schulze-Lohoff et al., 1992, 1995;Takeda et al., 1996
Myocytes
Cardiac	Yes	—	—	—	Quet al., 1993; Scamps and Vassort, 1994
Gastrointestinal	Yes	Yes	—	—	Blottièreet al., 1996; Pacaud et al., 1996
Vascular	—	Yes	—	—	Erlinge et al., 1995; Pacaud et al., 1995; Guibert et al., 1996;Malam-Souley et al., 1996; Strøbæk et al., 1996; Qasabian et al., 1997
Osteoblasts	Yes^14-d	Yes	—^14-j	—	Bowleret al., 1992; Sistare et al., 1994, 1995; Reimer and Dixon, 1992; Gallinaro et al., 1995; Dixon et al., 1997b
Ovarian granulosa cells
Human	—	Yes	—	—	Kamada et al., 1994;Lee et al., 1996
Porcine	Yes^14-d	Yes	—^14-j	—	Kamadaet al., 1994
Ovarian CHO cells	Yes	Yes	—	—	Iredale and Hill, 1993
Pancreatic β cells	Yes	—	—	—	Bertrand et al., 1987; Hillaire-Buys et al., 1994
Pheochromocytoma PC12 cells	Yes	Yes	—	—	Murrin and Boarder, 1992; Majid et al., 1992, 1993; Barry and Cheek, 1994; Nikodijevic et al., 1994; de Souza et al., 1995; Koizumi et al., 1995b
Pituitary cells
Gonadotrophs	—	Yes	—	—	Chen et al., 1994b, 1995b
Lactotrophs	—	Yes	—	—	Carewet al., 1994
Salt gland cells	Yes	Yes	—	—	Martin and Shuttleworth, 1995
Schwann cells	Yes	Yes	—	—	Berti Mattera et al., 1996; Ansselin et al., 1997; Green et al., 1997
Smooth muscle
Gastrointestinal	—	Yes	—	—	Johnson et al., 1996
Vascular	Yes	—	—	—	Kennedy and Burnstock, 1985; Mathieson and Burnstock, 1985; Burnstock and Warland, 1987; Liu et al., 1989; Brizzolara and Burnstock, 1991; Keefet al., 1992; Corr and Burnstock, 1994; Simonsen et al., 1997
	—	Yes	—	—	Eltze and Ullrich, 1996; Miyagi et al., 1996a; Malam-Souley et al., 1996; Rubino and Burnstock, 1996; Qasabian et al., 1997
	—	—	—	Yes	Von Kügelgen et al., 1987, 1990; Saiag et al., 1990, 1992; Ralevic and Burnstock, 1991b; Juul et al., 1992; Lagaud et al., 1996;Matsumoto et al., 1997
Thyrocytes	—	Yes	—	—	Schöfl et al., 1995
Trophoblastic cells (placental)	—	Yes	—	—	Petit and Belisle, 1995
Tumor cells
Ehrlich ascites	—	Yes	—	—	Dubyak and De Young, 1985
HTC liver cell line	—	Yes	—	—	Fitz and Sostman, 1994
Osteosarcoma	Yes	—	—	—	Kumagai et al., 1991

↵14-a P2Y₁-like, P2Y receptors other than P2Y₂, P2Y₄, P2Y₆, P2Y _ADP, and endogenous uridine nucleotide-specific receptors; probably P2Y₁ receptors (based on sensitivities to 2MeSATP and/or ADP, and signalling pathways), although other P2Y subtypes cannot be excluded.
↵14-b P2Y₂-like, activated by ATP = UTP suggesting a possible identity as P2Y₂ receptors, although at least in rat tissues a P2Y₄ subtype identity cannot be excluded (as rat P2Y₄ receptors are activated by ATP = UTP). The possible presence of uridine nucleotide-specific receptors cannot be excluded in tissues responding to UTP.
↵14-c ADP-specific P2Y receptors, activated by ADP but not by ATP.
↵14-d Denotes ADP-specific P2Y receptors (ATP weak or inactive); note that this is also the agonist profile of P2Y _ADPreceptors.
↵14-e These may be the same P2Y₁-like receptor.
↵14-f The response to UTP was distinct from that to UDP, but it is not clear whether this is via actions at a P2Y₂- or P2Y₄-like receptor.
↵14-g UTP was five-fold more potent than ATP, thus uridine-nucleotide-specific receptors are possible.
↵14-h Subtype(s) not clear: stimulation of PGE₂ production by ATPγS ≥ UTP > ATP.
↵14-i P2Y₆ (Nicholas et al., 1996).
↵14-j P2Y _ADP receptors have been described; however, it is likely that these are ADP-specific P2Y receptors.