Functions of Hsp families
| Family | Major functions | References |
|---|---|---|
| Hsp100 | Protein disaggregation, thermotolerance | Schirmer et al., 1996 |
| Hsp90 | Regulatory interactions with signaling proteins, stabilization of misfolded proteins | Csermely et al., 1998 |
| Hsp70 | Protein folding, membrane transport of proteins | Hartl, 1996 |
| Hsp60 | Protein folding (limited substrates in eukaryotic cytoplasm) | Hartl, 1996; Buchner, 1996 |
| Hsp40 | Protein folding, co-chaperone for Hsp70 | Cyr, 1997 |
| Small Hsp | Stabilization of misfolded proteins, thermotolerance, eye lens structural proteins | Buchner, 1996 |