Table 6

Single-channel conductance levels for various glutamate receptor subunit combinations

ReceptorpS%pS%pS%References
GluR2flip6-a 6-b 0.4 Swanson et al., 1997b
GluR4flip6-b 2481518874 Swanson et al., 1997b
GluR4flip/GluR2108492 Swanson et al., 1997b
GluR5(R)6-b - 6-d 0.2 Swanson et al., 1996
GluR5(R)/KA26-d 1.0 Swanson et al., 1996
GluR5(Q)6-b 6-d 1412967521 Swanson et al., 1996
GluR5(Q)/KA26-d 175918577 Swanson et al., 1996
GluR6(R)6-b 6-d 6-e 0.35 Howe, 1996; Swanson et al., 1996; Traynelis and Wahl, 1997
GluR6(R)/KA26-d 6-e 0.65 Howe, 1996; Swanson et al., 1996
GluR6(Q)6-b 6-d 2541515881 Swanson et al., 1996
GluR6(Q)/KA26-d 2061220774 Swanson et al., 1996
NR1-1a/NR2A51773823 Stern et al., 1992, 1994
NR1-1a/NR2B51833917 Stern et al., 1992
NR1-1a/NR2C36751925 Stern et al., 1992
NR1-1a/NR2D35611739 Wyllie et al., 1996
NR1-1a/NR2A/N75ND35ND Das et al., 1998
  • The three largest slope or chord single-channel conductance levels are shown for steady-state activation of recombinant glutamate receptors. Unless stated otherwise, glutamate (GluR1-6) or glutamate plus glycine (NR1/NR2A-D) were applied and responses were recorded in 0.85 to 1.0 mM external Ca2+. The relative proportion of openings to each level is indicated as percent. ND, not determined.

  • 6-a Similar results were obtained for both GluR2flip and GluR2flop.

  • 6-b Homomeric receptors.

  • 6-c Receptors were pretreated with concanavalin A.

  • 6-d Receptors were activated by domoate.

  • 6-e Receptors were activated by kainate; conductance was determined by variance analysis.

  • 6-f Channel openings were recorded nM levels of extracellular Ca2+; conductance levels may arise from separate channels.