Table 1

Cytochromes P-450 and phenacetin O-deethylase activity in rat liver and intestine after induction

TissueTreatmentTotal Cytochrome P-450CYP1A1CYP1A2Phenacetin O-Deethylase Activity
pmol/mg microsomal protein pmol/min/mg protein
LiverUntreated722  ± 5<0.59.0  ± 0.659.7  ± 6.4
3-MC984  ± 4356  ± 60124  ± 221600  ± 154
ISF1030  ± 4106  ± 32183  ± 42
IntestineUntreated45.7  ± 8.3<0.5<2<0.2
3-MC116  ± 18107  ± 14.5<215.4  ± 4.57
ISFND9  ± 0.6<2
  • Data were adapted from Sesardic et al. (1990). Rats were treated with 3-MC (80 mg/kg i.p.) for 48 h or ISF (160 mg/kg/day i.p.) for 4 days before sacrifice. ND, not determined.