Tissue | Treatment | Total Cytochrome P-450 | CYP2B1/2 | Ethoxycoumarin O-Deethylase Activity |
---|---|---|---|---|
pmol/mg microsomal protein | pmol/min/mg protein | |||
Liver | Untreated | 735 ± 143 | Undetectable | 862 ± 83.9 |
PB | 2200 ± 273 | 1056 ± 133 | 2550 ± 332 | |
Intestine | Untreated | 84.3 ± 16.8 | Undetectable | 57.9 ± 6.6 |
PB | 199 ± 17.4 | 107 ± 9.3 | 173 ± 36.9 |
Data were adapted from Bonkovsky et al. (1985). Rats were treated with PB (80 mg/kg i.p.) for 5 days before sacrifice.