Table 2

Cytochromes P-450 and ethoxycoumarin O-deethylase activity in rat liver and intestine after PB treatment

TissueTreatmentTotal Cytochrome P-450CYP2B1/2Ethoxycoumarin O-Deethylase Activity
pmol/mg microsomal protein pmol/min/mg protein
LiverUntreated735  ± 143Undetectable862  ± 83.9
PB2200  ± 2731056  ± 1332550  ± 332
IntestineUntreated84.3  ± 16.8Undetectable57.9  ± 6.6
PB199  ± 17.4107  ± 9.3173  ± 36.9
  • Data were adapted from Bonkovsky et al. (1985). Rats were treated with PB (80 mg/kg i.p.) for 5 days before sacrifice.