Activities of AHH and 7-ethoxycoumarin deethylase in the liver and small intestine of various animal species treated with PB and 3-MC
| Species | Tissue | AHH | 7-Ethoxycoumarin Deethylase | ||
|---|---|---|---|---|---|
| Control | 3-MC | Control | PB | ||
| relative fluorescence unit/min/mg microsomal protein | pmol/min/mg protein | ||||
| Rat | Liver | 7,164 ± 719 | 11,199 ± 609 | 500 ± 110 | 2,790 ± 150 |
| Small intestine | 40 ± 13 | 646 ± 137 | 49 ± 8 | 123 ± 19 | |
| Mouse | Liver | 919 ± 84 | 4,716 ± 602 | 1,600 ± 190 | 6,190 ± 250 |
| Small intestine | 50 ± 14 | 258 ± 64 | 64 ± 12 | 260 ± 23 | |
| Guinea pig | Liver | 1,266 ± 62 | 3,601 ± 65 | 1,050 ± 110 | 5,300 ± 610 |
| Small intestine | 408 ± 43 | 980 ± 207 | 92 ± 10 | 150 ± 30 | |
| Rabbit | Liver | 2,743 ± 478 | 1,635 ± 480 | 670 ± 100 | 3,700 ± 500 |
| Small intestine | 383 ± 95 | 316 ± 66 | 59 ± 20 | 41 ± 7 | |
Values are means ± S.E. (n = 4). Data were adapted from Miranda and Chhabra (1979). 3-MC was injected i.p. daily for 3 days in mice at a dose level of 100 mg/kg; in rats and guinea pigs, 25 mg/kg; and in rabbits, 25 mg/kg. PB was injected i.p. daily for 3 days in mice at a dose of 100 mg/kg; in rats and guinea pigs, 80 mg/kg; and in rabbits, 25 mg/kg.