Table 3

Activities of AHH and 7-ethoxycoumarin deethylase in the liver and small intestine of various animal species treated with PB and 3-MC

SpeciesTissueAHH7-Ethoxycoumarin Deethylase
Control3-MCControlPB
relative fluorescence unit/min/mg microsomal protein pmol/min/mg protein
RatLiver7,164  ± 71911,199  ± 609500  ± 1102,790  ± 150
Small intestine40  ± 13646  ± 13749  ± 8123  ± 19
MouseLiver919  ± 844,716  ± 6021,600  ± 1906,190  ± 250
Small intestine50  ± 14258  ± 6464  ± 12260  ± 23
Guinea pigLiver1,266  ± 623,601  ± 651,050  ± 1105,300  ± 610
Small intestine408  ± 43980  ± 20792  ± 10150  ± 30
RabbitLiver2,743  ± 4781,635  ± 480670  ± 1003,700  ± 500
Small intestine383  ± 95316  ± 6659  ± 2041  ± 7
  • Values are means ± S.E. (n = 4). Data were adapted from Miranda and Chhabra (1979). 3-MC was injected i.p. daily for 3 days in mice at a dose level of 100 mg/kg; in rats and guinea pigs, 25 mg/kg; and in rabbits, 25 mg/kg. PB was injected i.p. daily for 3 days in mice at a dose of 100 mg/kg; in rats and guinea pigs, 80 mg/kg; and in rabbits, 25 mg/kg.