Table 4

Cytochromes P-450 and erythromycin demethylase activity in rat liver and intestine after DX treatment

Tissue	Treatment	CYP3A1/2	Erythromycin Demethylase
		pmol/mg microsomal protein	pmol/min/mg protein
Liver^4-a	Untreated	<50	880 ± 260
	DX	330	2,220 ± 470
Intestine^4-b	Untreated	1^4-c	1,750
	DX	3–4^4-c	3,300

↵4-a Data adapted from Watkins et al. (1989). Rats were treated with DX (20 mg/kg p.o.) for 2 days before sacrifice.
↵4-b Data adapted from Watkins et al. (1987). Rats were treated with DX (20 mg/kg p.o.) for 2 days before sacrifice.
↵4-c Arbitrary units.