Table 1

Main antagonists and agonists of endothelin receptors

ETa Antagonists	ETb Antagonists	Mixed ETa/ETb Antagonists	ETb Agonists
BMS-182874	BQ-788^1-a	PD-142-893	STX^1-a
BMS-193884	IRL-1038^1-a	Ro-47-0203(Bosentan)^1-a	BQ-1620^1-b
BQ-123^1-a ^1-b	RES-701-1^1-a	SB-209670^1-b	IRL-3020^1-a
BQ-485^1-b	IRL-2500	SB-217242
BQ-610^1-a	Ro-468443	Ro-485695
PD-147953 (FR-139317)
PD-151242^1-a

↵1-a BQ-123 and SB-209670 are reported to be selective for ETa ₁ and ETb ₂ receptor subtypes, respectively (Ohlstein et al., 1996).
↵1-b Ligands used in the studies reviewed in the present survey.