Opioid Antinociception | Inhibited by Antisera or AS Oligo Against | Not Inhibited by Antisera or AS Oligo Against |
---|---|---|
Supraspinal δ antinociception | Giα2 (1, 6, 7) | Giα1 (6, 7) |
Giα3 (5, 7) | Gx/z (1, 6, 7) | |
Gs (4) | ||
Spinal δ antinociception | Giα1 (8) | |
Giα2 (8) | ||
Giα3 (8) | ||
Gx/z (8) | ||
Go(8) | ||
Gq (8) | ||
Supraspinal κ antinociception | Giα1 (8) | Giα2 (8) |
Giα3 (8) | Go (8) | |
Gx/z (8) | ||
Gs (8) | ||
Gq (8) | ||
Spinal κ antinociception | Gq (8) | Giα1 (8) |
Giα2 (8) | ||
Giα3 (8) | ||
Gx/z (8) | ||
Go (8) | ||
Gs (8) | ||
Supraspinal μ antinociception | Giα2 (1, 2, 3, 6, 7, 8) | Giα1(2, 3, 6, 7, 8) |
Gx/z (1, 6, 7) | Giα3 (2, 5, 7, 8) | |
Go (8) | Gx/z (8) | |
Gs (4, 8) | Go (3) | |
Gq (8) | ||
Spinal μ antinociception | Giα2 (8) | Giα1 (8) |
Gx/z (2) | Giα3 (8) | |
Go(8) | ||
Gq (8) | ||
Gs (8) |
References: 1, Garzón et al., 1994; 2, Raffa et al., 1994; 3,Rossi et al., 1995; 4, Sánchez-Blazquez and Garzón, 1992; 5,Sánchez-Blazquez et al., 1993; 6, Sánchez-Blazquez and Garzón, 1993; 7, Sánchez-Blazquez et al., 1995; 8, Standifer et al., 1996.