Toxicity | Effect of Liposome Encapsulation |
---|---|
Cardiac toxicity | Reduced or not observed |
Myelosuppression | Reduced (to a greater extent with SSLs) |
Mucositis | Slightly increased with Doxil |
Alopecia | Reduced or not observed |
Severe local tissue necrosis after drug extravasation | Reduced |
Nausea and vomiting | Reduced or not observed |
H-F syndrome | Observed with Doxil or with continuous infusion of free DOX |