Table 3

Pharmacokinetic parameters of SSL DOX in various animals

Animal Model	Formulation	Dose	T_1/2	AUC	V_d	CL
		mg/kg	h	mg ∗ l/h	ml	ml/h
Rats^3-a	SSL DOX	1.0	T ₁ = 1.8	683	13	0.4
			T ₂ = 23.6
	Free DOX	0.9	T ₁ = 0.16	11.1	1,014	24.3
			T ₂ = 29.1
Male Sprague-Dawley rats^3-b	HSPC/Chol/PEG-DSPE (37:20:3)	6.0	T ₁ = 2.8	2,769	18	0.5
			T ₂ = 22
	Free epirubicin	6.0	0.23	15	3,700	111
Rabbits^3-a	SSL DOX	1.0	T ₁ = 0.5	368	176	6
			T ₂ = 21.3
	Free DOX	1.0	T ₁ = 0.03	1	13,651	2,536
			T ₂ = 4.07
Dogs^3-a ^3-c	SSL DOX	1.5	T ₁ = 0.20	656	596	15.5
			T ₂ = 25.9
	SSL DOX	0.5	27 ± 5	304 ± 118	1000 ± 100	25.2 ± 7.2

T ₁, half-life associated with the first exponent of elimination; T ₂, half-life associated with the second exponent of elimination; V _d, volume of distribution; CL, total plasma clearance.
↵3-a Working and Dayan (1996).
↵3-b Mayhew et al. (1992).
↵3-c Gabizon et al. (1993).