Formulation | Dose | T1/2 | AUC | Vd | Cl | Reference |
---|---|---|---|---|---|---|
mg/m2 | h | mg ∗ h/l | l | l/h | ||
SSL DOX | 25 | 3.2 (0.2–5.4) | 609 | 4.1 | 0.08 | Gabizon et al. (1994) |
45.2 (20.8–59.1) | (227–887) | (3.0–6.5) | (0.05–0.21) | |||
50 | 1.4 (0.2–7.3) | 902 | 5.9 | 0.09 | Gabizon et al. (1994) | |
45.9 (29.3–74.0) | (335–2497) | (2.3–10.1) | (0.03–0.24) | |||
Free DOX | 25 | 0.07 (0.05–0.09) | 1.0 | 254 | 45.3 | Gabizon et al. (1994) |
8.7 (3.6–13.3) | (0.7–1.3) | (126–393) | (39.7–48.6) | |||
50 | 0.06 (0.06–0.08) | 3.5 | 365 | 25.3 | Gabizon et al. (1994) | |
10.4 (5.4–26.8) | (2.6–6.0) | (131–501) | (13.3–35.2) | |||
SSL DOX | 20 | 5.6 | 577 | 4.7 | 0.07 | Working and Dayan (1996) |
56.6 | ||||||
TLC D-99 | 20 | 0.71 ± 0.37 | 30.4 ± 32.5 | 21.4 ± 14.0 | 23.5 ± 15.6 | Cowens et al. (1993) |
8.2 ± 6.2 | ||||||
25 | 0.29 ± 0.09 | 19.7 ± 17.7 | 18.8 ± 10.7 | 23.3 ± 15.7 | ||
6.68 ± 2.94 | ||||||
30 | 0.37 ± 0.16 | 50.5 ± 44.9 | 8.2 ± 3.0 | 9.0 ± 7.8 | ||
25.0 ± 22.5 | ||||||
90 | 0.45 ± 0.60 | 14.1 ± 16.6 | 14.6 ± 7.8 | 21.8 ± 15.5 | ||
13.5 ± 6.6 | ||||||
TLC D-99 | 30 | 0.2 ± 0.1 | 30.4 ± 25.8 | 7.1 ± 4.0 | 9.8 ± 10.7 | Conley et al. (1993) |
25.1 ± 35.5 | ||||||
DSPC/Chol (2:1) | 10 | 2.8 | 16.9 | 3.75 | 0.942 | Gill et al. (1995) |
(daunorubicin) | 20 | 3.8 | 57.2 | 4.1 | 0.858 | |
40 | 4.0 | 120.1 | 3.7 | 0.630 | ||
60 | 8.3 | 301.1 | 2.9 | 0.402 | ||
80 | 5.2 | 375.3 | 2.9 | 0.396 | ||
Free daunorubicin | 80 | 0.77 | 10.33 | 1055 | 13.38 | Forssen and Ross (1994) |
DSPC:Chol (55:45) (VCR) | 2.0 | 1.95 ± 1.67 | 6.5 ± 0.6 | 4.35 ± 0.84 | Embree et al. (1998) | |
22.5 ± 9.85 | ||||||
2.8 | 7.2 ± 4.8 | 40.2 ± 17.2 | 2.26 ± 0.47 | |||
99.3 ± 17.2 |
Errors are expressed as either a range (in parentheses) or as a S.D., depending on the source of the data. For expression of half-lives of elimination, the top value is the half-life associated with the first exponent of elimination, and the bottom value is the half-life associated with the second exponent of elimination.
T 1/2, half-life elimination of drug from the circulation; V d, volume of distribution; Cl, total plasma clearance.